On the 10th, I learned from the website of the Chinese Academy of Sciences that Yu Xuefeng, a researcher at the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, has collaborated with Zhang Jian, a professor at the Shenzhen University, and Zhu Jianhao, a professor at the City University of Hong Kong, to successfully prepare a biodegradable photothermal conversion material based on black phosphorus. To achieve efficient and safe tumor photothermal therapy. Nanophotothermal therapy technology has the advantages of wide application scope, non-invasiveness, strong selectivity, simple process, and minimal damage to normal tissues. It has shown great application value in the fields of tumor therapy, controlled drug release, and light-controlled implant materials. However, the currently used inorganic nano-photothermal conversion materials are often not degradable in vivo, but remain in the organ in the form of nano-particles for a long time, or the degradation products of the materials contain toxic substances, which will initiate the potential toxicity reaction of the organism. It has made it difficult for them to obtain approval from international medical review bodies (such as the FDA) and has entered practical clinical applications. Research and development of superior performance and biodegradable nanomaterials are key and difficult to push nanotechnology to practical clinical applications. Black phosphorus is a direct bandgap Semiconductor Material with a two-dimensional layered structure that has attracted wide attention in recent years and exhibits excellent electrical and optical properties. In the previous study, the Yu Xuefeng team found that black phosphorus quantum dots with a size of just a few nanometers have a high near-infrared thermal conversion capability (Angew. Chem. Int. Ed. 2015, 54, 11526). In addition, black phosphorus oxidizes under physiological conditions and degrades into safe small molecule products such as phosphate ions and phosphite ions (Angew. Chem. Int. Ed. 2016, 55, 5003). However, recent studies have found that exposed black phosphorus is degraded too quickly in a physiological environment, which can cause its optical performance to decline during the circulation of the body, thereby affecting the effect of photothermal therapy. In response to this problem, the research team used the emulsification solvent evaporation method to prepare a core-shell structure nanospheres (BPQDs/PLGA) with high molecular weight polymer (PLGA)-encapsulated black phosphorus quantum dots (BPQDs). PLGA is a biodegradable hydrophobic biopolymer. The polymer shell formed can separate the internal black phosphorus quantum dots from the physiological environment, ensuring the stable performance of the black phosphorus quantum dots in the treatment process. After the photothermic treatment is completed, the black phosphorus quantum dots will slowly release and degrade with the gradual degradation of the PLGA shell, and then be safely metabolized out of the body. Cell and animal experiments have shown that BPQDs/PLGA has good biological safety and passive targeting of tumors, and exhibits high photothermal therapeutic efficiency. Implementation of near-infrared light for five minutes can effectively kill tumors. . The successful development of this new type of biodegradable photothermal conversion material will undoubtedly promote the actual clinical application of photothermal therapy technology and provide guidance and reference for future biomedical applications of nanomaterials. The research team has applied for relevant invention patents and is actively promoting the application of relevant clinical application licenses, and strives to use them for clinical purposes as soon as possible. Molecular formula of Trifluoroiodomethane is CF3I and its molecular weight is 195.91. Trifluoroiodomethane is a kind of colorless and odorless gas. It is non-toxic, fireproof, oil soluble and well-materials compatibility. It is one of the substitutes of traditional freon refrigerant with characteristics of high extinguishing efficiency, good safety performance and well economic benefit. Trifluoroiodomethane Shandong Zhongshan Photoelectric Materials Co., Ltd , https://www.chzsem.com